Probiotics May Relieve Depression

Maylin Rodriguez Paez RN

Probiotics, which are typically known for their effects on the digestive tract, are becoming a hot topic in the field of psychology. Previous research shows a potential role in alleviating anxiety.1

And now, a recent study suggests that probiotics may even help to alleviate depression. The results were published in the journal, Brain, Behavior, and Immunity.

Probiotics Reduce Sad Thoughts

Rumination, which is the repetition of negative thoughts, is a risk factor for depression. Scientists from the Leiden Institute for Brain and Cognition wanted to investigate if probiotics could play a role in the treatment of the disease.

For the study, 20 individuals without mood disorders were given probiotics for a period of four weeks. Another group of 20 people were given a placebo for the same period of time. Both groups were asked to fill questionnaires which measured their mood.

The probiotics were composed of different species including Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, and Lactococcus lactis (W19 and W58). 

Compared to the control group, participants taking the probiotics were less likely to experience ruminative thoughts.2 This is the first study of its kind to show that probiotics have this effect on people.

How Are the Brain and Gut Connected?

The exact mechanism behind the results of this study is unknown. What we do know is that gut bacteria play a key role in the production of neurotransmitters.

For example, it’s estimated that about 90% of the body’s supply of serotonin (a key neurotransmitter implicated in depression) is made in the digestive tract. This phenomenal task is regulated by certain species of gut bacteria whose elimination has been shown to reduce serotonin levels.3

This may potentially explain why certain illnesses such as IBS are connected with depression.

Although this field of research is new, it provides insight into the complex relationships between the gut and brain. In the future, perhaps we’ll see holistic treatments for depression which not only focus on the brain, but on the gut too.


  1. Br J Nutr. 2011 Mar;105(5):755-64. Epub 2010 Oct 26. 
  2. Brain Behav Immun. 2015 Apr 7. 
  3. Cell. 2015 Apr 9;161(2):264-76. doi:10.1016/j.cell.2015.02.047.


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C.Ernst said...

Is there a way to get all of the probiotics that were used and if they were all given to everyone or if they were split between participants?

Life Extension said...

C.Ernst- In the probiotics intervention, participants were provided with 28 sachets (one for each day of intervention), each containing 2 g freeze-dried powder of the probiotic mixture Ecologic®Barrier (Winclove probiotics, The Netherlands). Here's the actual study:

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