Iron Accumulation Worsens Alzheimer’s Disease

By Michael A. Smith, MD

Every 68 seconds, someone in America develops Alzheimer’s disease. Unfortunately, this rate is projected to more than double by 2050, increasing to one every 33 seconds.1

And although Alzheimer’s research is accelerating, there's still no cure to speak of.

However, oxidative stress could be an underlying factor in initiating Alzheimer’s disease.

Pro-oxidants from our environment and from aging itself appear to activate the genes involved in producing amyloid-beta protein – the hallmark of Alzheimer's disease.2

Pro-oxidants in the brain damage brain cells, resulting in an accumulation of iron on their cell surfaces. Once the iron (another powerful pro-oxidant) accumulates, more damage ensues, leading to additional amyloid-beta production.

This new finding offers hope for intensive antioxidant therapy and iron chelation as possible future treatments for this devastating disease.

Watch our own Dr. Mike Smith explain in the short video below:


  1. Alzheimers Dement. 2012;8(2):131-68.
  2. Neurobiol Aging. 2013 Apr;34(4):1069-79


Lynda said...

Very interesting ... Good thing I have almost no iron in my diet! I guess I could afford to have a little more.

Elvira said...

Iron is still essential mineral, especially for women. People should worry more about useless heavy metal accumulation such as Aluminum (which was directly linked to Alzheimer's) and mercury. Both are found in food and body care products and both are dangerous. I wouldn't worry about Iron, since many people are actually deficient rather than have too much.

Anonymous said...

Flouride may attract Aluminum accumulation in the brain

Life Extension said...

Lynda - An iron blood test can reveal your iron status, but overall post menopausal women shouldn't supplement with iron unless they have a diagnosed deficiency.

Stephen in Alabama said...

I am very hopeful that they will be able to turn this research into some better forms of treatment, like a more intensive antioxidant therapy. Will definitely be following further developments that come from this research.

Life Extension said...

Stephen in Alabama - We hope that's the case as well!

Post a Comment

All Contents Copyright ©2020 Life Extension® All rights reserved.
Privacy Notice | Terms of Use
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.