Thymoquinone Fights Against Seasonal Allergies

By Michael A. Smith, MD

Black cumin seed oil contains a known immune modulator that could potentially help millions of people dry up their sinuses.

Now, we’re not talking about the spice cumin — that’s a totally different plant species from black cumin. This is something else entirely.

So, although I would always advise to cook liberally with cumin, it probably won’t help your runny, itchy nose. Sorry.

But black cumin, however, may very well help because it provides thymoquinone — an immune modulator.

Let's explore how it works.

Allergies and Your Immune System

Your immune system requires specific proteins, also called cytokines or interleukins, to communicate between white blood cells. This elaborate communication network allows for coordinated attacks against bacteria, viruses and sometimes innocent grasses, trees and even foods.

The immune system doesn't discriminate against anything that it perceives as potentially harmful — including living things found in nature. The seemingly innocent allergens from nature enter your body through the air and elicit an immune attack, all coordinated by those immune system proteins.

With allergens in your body, the proteins activate B-cells to produce an antibody called IgE. This in turn can increase the production of a number of different immune cells, including histamine releasing mast cells. The end result is a surge of histamine that causes the allergy symptoms you have grown to hate.

Thymoquinone Helps Control Several Immune Proteins

Thymoquinone, found in black cumin seed oil, has actually been shown to help control or modulate the production and release of the immune proteins explained above.1,2

So what does this mean for you? Well, it could mean less histamine release, fewer allergy symptoms, and less frustration with your immune system overall.

A quick disclaimer though - the studies showing thymoquinone’s specific effect on immune proteins were conducted in conjunction with common allergy medications. The studies in the next section below, however, were conducted using thymoquinone exclusively.

Thymoquinone Improves Allergy Symptoms

In four studies, 152 patients with allergic rhinitis and asthma were treated with black cumin seed oil standardized to thymoquinone.3

The researchers studied the subjective severity of symptoms and some objective allergy measurements, including IgE antibody levels, eosinophil count, endogenous cortisol and ACTH. And because it’s a healthy oil, they also checked total cholesterol, LDL, HDL and triglycerides.

The following results were published:

  • The score of subjective allergy symptoms improved in all four studies.
  • There was a decrease in IgE levels and eosinophil count.
  • Plasma triglycerides decreased and HDL cholesterol increased.
  • Cortisol levels and ACTH release remained unchanged.
The authors concluded that black cumin seed oil “proved to be an effective adjuvant for the treatment of allergic diseases.”

Pretty interesting, isn’t it?


  1. J Ethnopharmacol. 2011 Sep 2;137(2):1028-34.
  2. Egypt J Immunol. 2005;12(1):95-102.
  3. Phytother Res. 2003 Dec;17(10):1209-14.


Anonymous said...

I have found perilla leaf quite helpful. Could I try black cumin at the same time?

LifeExtension said...

Anonymous - We don't see why not. ;-)

Anonymous said...

haha great! Do they work through different pathways?

LifeExtension said...

Anonymous - They share a common mechanism of action. For example, both inhibit mast cells from releasing histamine, the compound that causes uncomfortable allergy symptoms.

Anonymous said...

Thymoquinone also helps potentiate opiod painkillers for a bit of extra relief and it is also used in some poorer countries to help relieve opiod withdrawal.

Nigella Sativa is a pretty cool little plant in my opinion.

LifeExtension said...

Anonymous - It's definitely a cool plant! Thanks for reading. :-)

Anonymous said...

Could it be safely taken at the same time as a corticosteroid nasal spray? Any bad interactions known?

LifeExtension said...

Anonymous - We're not aware of any known interactions but to avoid potential interactions it is best to take supplements at least 2 hours apart from meds. As a precaution you should always work with a doctor.

ragweed allergy symptoms said...

I am visiting this blog for first time. I am proud to say that I’ve become a great fan of this blog officially. A good blog always comes-up with new and exciting information like this one. Anyone who really wants to read a article with full of information, should read this.

Unknown said...

A couple of drops into each nostril following nasal lavage is remarkably good a clearing the nasal passages. Try it before bed and you will wake up clearer than you have been in years. Extremely important only to use pure cold pressed and chemical extraction free black seed oil.

Life Extension said...

Nabi Blackseed - Interesting! We'll have to give that a try.

Post a Comment

All Contents Copyright ©2020 Life Extension® All rights reserved.
Privacy Notice | Terms of Use
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.