Can Probiotics Help Reduce Anxiety?

Maylin Rodriguez-Paez, RN

Normally, we think of probiotics as digestive supplements. However, more and more research is showing that they could do much more than help your gut.

In fact, a double-blind placebo controlled study found that two probiotic strains, Lactobacillus helveticus R0052 and Bifidobacterium longum R0175, actually alleviated symptoms of anxiety.

The French researchers also found those treated had lower levels of cortisol, a hormone which elevates due to stress.1

This research is actually pretty interesting. It’s beginning to paint a clearer picture of how our gut can influence our minds and emotions. This might explain why stressful situations may cause “butterflies” in our stomachs and wreak havoc on our digestive system.

But just how is it that probiotics influence our mood? The science isn’t 100% clear, but we’ll explore some ideas below.

Probiotics Boost Neurotransmitters and Lower Inflammation

Scientists have referred to the gut as the “second brain.” Why? Because it contains a vast network of neurons. In fact, it contains over 100 million neurons, which is more that what’s found in your spinal cord.2

Just like the neurons in your brain, the neurons in your gut communicate with neurotransmitters. One particular nerve, called the vagus nerve, communicates directly to your brain. This is why your digestive system responds to stress and outside stimuli.

Rat studies show probiotics increase the number of GABA receptors3 in the brain and the production of GABA4, a neurotransmitter which supports rest and relaxation. The anti-anxiety class of meds called benzodiazepines work by modulating GABA levels.

Probiotics also lessen gut inflammation.5 The French scientists think this is one possible mechanism behind its mood enhancing effects. Studies indicate that inflammation is tied to mental health problems like anxiety.6

How to Get More Probiotics Into your System

Yes — yogurt does contain probiotics. However, they only supply a small dose of beneficial bacteria. For more therapeutic effects, we suggest a high quality probiotic supplement.

And not all probiotics are created equal — there are many strains and preparations on the market. It’s important that you actually get the clinically effective strains in whatever product you choose. Remember, the French study used Lactobacillus helveticus and Bifidobacterium longum.

The amount of live bacteria is important as well. Look for products that contain several billion CFUs per serving. That way you’ll increase the odds of the probiotic colonizing your gut. It’s also important that you take your probiotics frequently so that the dying bacteria are replaced.

What You Need to Know

Can probiotics help you feel less anxious? Possibly. As is often the case, more research needs to be done to come to a solid conclusion.

What we do know is that scientists are uncovering new ways that your mind is connected to your gut. Specifically, science is now suggesting that mental health is not just about your brain; it’s about your gut too.

What do you think?


  1. Br J Nutr. 2011 Mar;105(5):755-64. Epub 2010 Oct 26.
  2. Available at: Accessed October 8th 2012.
  3. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5. Epub 2011 Aug 29.
  4. Biosci Biotechnol Biochem. 2008 Feb;72(2):278-85. Epub 2008 Feb 7.
  5. Gut Microbes. 2012 Jan-Feb;3(1):25-8. Epub 2012 Jan 1.
  6. Gastroenterology. 2010 Dec;139(6):2102-2112.e1. Epub 2010 Jun 27.


Donna from Personal Trainer said...

I believe on the power of probiotic for healthy digestion but I never knew that it can also reduce anxiety.I always eat yogurt.It's very healthy.

Life Extension said...

Donna from Personal Trainer- It’s amazing what probiotics can do, isn’t it? Thanks for chiming in!

ss said...

can u recommend a good probiotic? There r soooo many out there, it's hard to know which r good and which r not.

Life Extension said...

ss: We like a product called Theralac, because the strains it contains have been used in studies and are proven to be effective. Also, many of our customers have had great results with it. Hope this helps!

Maggie said...

You will be surprised at what you discover if you treat your body well. I found that by drinking more water, I felt better than anything I could have added to diet.

Anonymous said...

Are you saying you should take probiotics on a daily basis?

Unknown said...

I am allergic to all dairy other than egg whites. Would Theralac be something I could add to my LE supps?

Unknown said...

I am allergic to all dairy products except egg whites. Would Therlac be something I could add to my current LE supps?

LifeExtension said...

Anonymous - It depends on the brand. When you start taking probiotics you may have to take them daily for a short period of time, but afterwards you could take them several times a week for maintenance.

LifeExtension said...

Debra Cross Desrochers - It's very unlikely that Theralac would cause a milk related allergy. More info here:

Anonymous said...

Interesting to say the least!!!!!!! :)

LifeExtension said...

Anonymous - Thank you!

Post a Comment

All Contents Copyright ©2021 Life Extension® All rights reserved.
Privacy Notice | Terms of Use
These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.