How to Naturally Enhance Libido Through Brain Chemistry

By Michael A. Smith, MD

One of the distressing side effects of the aging process is low libido, which is manifested as a loss of sexual desire, enjoyment, and performance.

Dr. Eric Braverman, a brain and aging specialist, says that aging affects all parts of the body linked with sexual function both internally and externally.1 In men, greater physical stimulation is required to attain and maintain erections, and orgasms are less intense due to brain, hormonal, and vascular factors.

In women, menopause contributes to sexual decline, partly as a result of physical symptoms like vaginal dryness, hot flashes, and weight gain.

Despite physician efforts to treat low libido with bio-identical hormones, men and women may not experience an improvement in sexual function. Are we missing something?

Libido – It Really Is All in Your Head

Treating low libido with hormones often falls short because it neglects one of the most important organs for a healthy sex life … your brain. The components of healthy libido — desire, arousal, orgasm, and resolution — are all controlled by brain chemicals called neurotransmitters.

In order for you to improve your sex drive, you need to optimize the following neurotransmitters:

  • Dopamine for Desire
  • Acetylcholine for Arousal
  • GABA for Orgasms
  • Serotonin for Resolution
Let’s take a look at some natural strategies for boosting these important brain chemicals and improving libido.

Restore Sex Drive with Dopamine

It’s now well-established that dopamine affects sexual desire. As a matter of fact, medications that block dopamine receptors have been associated with decreased libido.

The good news is that libido can improve with the right combination of vitamins, minerals, natural treatments. Here are a few suggestions for boosting brain dopamine levels:3

  • Amino acids tyrosine and phenylalanine
  • Folic acid and thiamine (B1)
  • Chromium
  • Rhodiola rosea
  • Ginkgo biloba

Boost Sexual Arousal with Acetylcholine

According to Dr. Braverman, the brain chemical acetylcholine is responsible for arousal. It’s believed that people with low brain levels of acetylcholine are unable to concentrate on sex, hence disrupting the normal arousal process.4

For this reason, to improve arousal, you might consider the following acetylcholine boosters:3

  • Choline
  • DMAE
  • Acetyl-L-carnitine
  • Phosphatidylserine
  • Omega-3 fatty acids
  • Manganese

Enhance Orgasms with GABA

GABA is responsible for regulating sexual tone and plays an important role in overall brain function. Therapeutic drugs that increase the amount of GABA in the brain typically have relaxing, anti-anxiety, and mood-soothing effects.5,6

Conversely, when GABA becomes depleted, it is difficult to relax and let go of fear and negative feelings. Hence, orgasm becomes difficult. GABA-enhancing compounds include the following:3

  • GABA (available as a supplement)
  • Inositol
  • B Vitamins
  • Kava kava
  • Branched-chain amino acids (leucine, isoleucine, and valine)

Improve Sexual Resolution with Serotonin

The final phase of libido is resolution. This is established and maintained by the brain chemical serotonin, which modulates anger, aggression, body temperature, mood, sleep, and sexuality.7 Low serotonin levels can result in a lack of joy and decreased feelings of intimacy.

Without resolution, intimacy is lost. This can disrupt future sexual desire and arousal. If sexual intimacy and joy are issues for you, try optimizing brain serotonin levels.3 Here are some nutrients that can help:

  • Tryptophan
  • 5-HTP
  • Saffron extract
  • Omega-3 fatty acids
  • Magnesium

Putting It All Together

Healthy sexual function is crucial to overall well-being and longevity. And contrary to what many people think, it is possible to maintain youthful sexuality well into your golden years.

By using targeted nutrients to balance neurotransmitter profiles and optimize your hormone balance, you can be well on your way to enjoying better sex today.

Want to read more on this topic? Check out our magazine article on restoring youthful sexual function.


  1. Life Extension Magazine®. 2008 Oct;14(10):
  2. J Sex Med. 2007 Nov;4 Suppl 4:269-79.
  3. Braverman ER. Younger You: Unlock the Hidden Power of Your Brain to Look and Feel 15 Years Younger. New York, NY: McGraw-Hill;2007.
  4. Int J Impot Res. 2000 Oct;12 Suppl 4:S26-33.
  5. Cell Mol Neurobiol. 2008 Sep;28(6):803-17.
  6. Neurochem Res. 2008 Oct;33(10):1990-2007.
  7. J Vet Pharmacol Ther. 2008 Jun;31(3):187-99.


Tongkat Ali said...

I have many pals dealing alongside minimal sex disc drive and additionally it is because of early menopause. Hope the couple can get a hold of something that helps them, though.

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Stress has become a part of our DNA. We are always stressed – at work or at home. The only thing we do to drive away stress is gulp down a couple of whiskey shots, which add visceral fat inside us. Well, some amount of stress is good, but being stressed all the time releases the cortisol hormone in our body. Cortisol drops our testosterone levels and that reduces our sex drive. The lesson is that we must do anything (meditation, exercise, new job, vacation, etc.) to cut out stress from our life.

LifeExtension said...

cool sizegurus website - Yes, it's important to manage stress to maintain a healthy libido. Thanks for chiming in!

Oliver said...

Dear Dr S, For what its worth: Due to chronic stress & depression, etc. I haven't woken up with an erection in 2 years or more... Took a 5-HTP formulation last night for the first and woke up aroused, unbelievable! Sleep wasn't great, however: anxious heartbeat upon lying down followed by waking up way too early. Will experiment with dosage time, maybe not immediately before bed would be better? Also, tyrosine has helped me immensely with stress response and morning anxiety/heart racing. Would taking it at night along with 5-HTP help counteract the negative effects of the 5-HTP or is tyrosine better taken upon waking up? Well, I'm glad to be learning more about amino acids. Still have a lot of fine-tuning to do but I finally feel like there may be some improvement on the horizon.

LifeExtension said...

Oliver - If the 5-HTP is giving you an adverse reaction, we suggest that you discontinue it. We don't know if combining it with tyrosine would help. Perhaps you may want to try tryptophan instead of the 5-HTP. Just like the 5HTP, it supports serotonin synthesis. In addition, it may enhance sleep.

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It just so happens a low libido can be followed to what's in your head - truly.The mechanisms by which a healthy libido is cultivated,including desire and arousal,are controlled by brain chemicals called neurotransmitters.To improve your sex drive,you initially need to handle neurotransmitters like dopamine and serotonin and hormones like testosterone.
~Jessica Hall.

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Drug Discovery said...

The brain as a hidden organ in the process of forming libido often neglected by patients, then self-prescribed treatment can not address the problem. Dopamine is quite frequently mentioned in medications, improvement of its activities in right medication is quite important, hope there will be more related introduction on such topics.

Life Extension said...

Drug Discovery- Thanks for chiming in! :-)

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Unknown said...

I think stress has an important role in the libido, In my case I had a very low libido caused of my stress, I had 3 jobs and it kept me busy and stressed all the time, when i would get home the only thing i wanted was to sleep and eat, I didnt even want to "have action" with my gf and that was making us to get distant and after a time she letf made me get depressed, it took me some months to get over it . My friend recommended me to take things easy and relax more, also told me about a supplement named alpha rise that helped him a lot, I was aware i needed a solution for it so I followed his advice and it was magical guys, it helped me increasemy libido. I have a better lifestlye now, also a new and better gf.

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