How Diosmin Relieves Unsightly Varicose Veins

By Michael A. Smith, MD

For the last 30 years, millions of European women have been using a doctor-prescribed citrus fruit flavonoid extract to attain healthier, smoother legs.

Now, U.S. women have access to the same European drug without a doctor’s prescription as a nutraceutical product, called micronized diosmin. It has been clinically proven to produce healthier-looking legs by healing swollen ankles, spider and varicose veins, and leg ulcers.

While current U.S. drug treatments for cosmetic improvement in the legs have not achieved good clinical efficacy, micronized diosmin has enjoyed an outstanding 30-year record of research testing and success in Europe.1

It enhances the appearance of the legs by reducing ankle swelling, improving the appearance of varicose and spider veins, and restoring healthy vascular function in people suffering from chronic venous disorders.

Diosmin Protects the Microcirculation in Your Legs

The role of the legs’ venous system is to return deoxygenated blood from the lower extremities to your heart. To counterbalance the effect of gravity, leg veins are equipped with a series of one-way valves that prevent the return of blood flow to the feet.

In people with healthy venous valves, each contraction of the calf muscle pumps venous blood toward the heart. As valves become damaged, they allow retrograde flow of blood toward the feet, leading to hypertension in the veins and further complications linked to progression of chronic venous disease.

This leads to damage of the venous wall, the appearance of varicose veins, and further damage leading to the progression of venous disease.

It’s been postulated that micronized diosmin works by inhibiting the interaction between immune cells and the endothelium lining the vein. By doing this, the vein and valves are strengthened.

Diosmin protects capillaries and the microcirculation from inflammation and vascular-destructive compounds while inhibiting white blood cell activation, migration, and adhesion.

Likewise, micronized diosmin prevents tissue damage to blood vessel valves; preventing venous blood backflow.2-4

By the way, chronic venous insufficiency isn’t just a cosmetic issue. It’s a risk factor for phlebitis, an inflammatory venous condition that can cause deep venous thrombosis or clots. These clots can travel to the lungs and cause significant damage and even death.

Diosmin Completely Heals Venous Ulcers in Legs

A multicenter, randomized, controlled trial tested micronized diosmin in addition to standard compression stocking therapy versus placebo for two months in patients with leg ulcers.

The study group consisted of 140 men and women ranging in age from 18 to 85 years who were undergoing standardized local care of leg ulcer5.

A significantly larger number of patients (47% in the diosmin group vs. 28% in the placebo group) experienced complete healing of venous ulcers at the end of six months. Pretty impressive, right?

Why Micronized Diosmin?

Micronization is a technique that reduces the size of the particles and improves the rate of absorption of an otherwise poorly absorbed compound – such as diosmin.

It’s a widely accepted principle that the smaller the particles of a compound like diosmin, the better the absorption and ultimately the better the distribution throughout the body, a concept called bioavailability.

Micronized diosmin has been reduced from a mean particle size of 36.5 micrometers to a mean particle size of 1.79 micrometers. This significantly improved the gastrointestinal absorption of diosmin by at least 30%, and this increased bioavailability should result in improved efficacy.6

Also, micronized diosmin enjoys an outstanding safety record unrivaled by any other drug used to treat venous disorders.

Finally, the overwhelming majority of published studies show that diosmin is generally nontoxic at recommended doses, including studies involving pregnancy, and is relatively free from drug interactions.


  1. Angiology. 1994 Jun;45(6):419-28.
  2. Microcirculation. 2000;7(6 Pt 2):S29-S34.
  3. Angiology. 2001 Aug;52 Suppl 1S49-S56.
  4. Int Angiol. 1995 Sep;14(3 Suppl 1):36-8.
  5. Phlebology. 1999;14:151-7.
  6. J Pharm Sci. 2002 Jan;91(1):32-40.



Breast Enlargement said...

This one is very nicely written and it contains many useful facts. I am happy to find your distinguished way of writing the post.

LifeExtension said...

Breast Enlargement - Thanks for the feedback! We'll let Dr. Mike know. :)

Nellie said...

Very important and useful for me. I have one prominent varicose vein at the back of my knee and I'm afraid that more will eventually surface. This is the first time I learned about micronized diosmin and you presented it in a way that is understandable to ordinary folks.

LifeExtension said...

Nellie - We're glad the information was helpful. Thanks for reading!

Skin Laxity said...

Very nicely written post it contains useful information for me.Now you make it easy for me to understand and implement the concept. Thank you for the post.

LifeExtension said...

Skin Laxity - Our pleasure! Thanks for reading. :-)

Family Podiatry said...

Diomin absoption level through the human skin is actually very poor. I like the explanation that very well elaborated on the size reduction from 36.5 to 1.79 putting in mind that a micro meter is a very small unit.

Anonymous said...

Could you tell us what a recommended dose is? And if there is a time limit for taking this? Thank you.

LifeExtension said...

Anonymous - It's good to work with your doctor. Consider 600 mg daily for three months.

Pilingas said...

oh! finally.. the information I was looking for few hours. Thank you!

Life Extension said...

Pilingas - Glad it hit the spot!

Anonymous said...

Are there any studies for diosmin eradicating telangiectasia on the sclera of the eye?

Also, is it safe to take for longer than 6 months?

DrJayUSA said...

Hello, I love your blog. I'd like to add a little. Varicose veins are enlarged, convoluted veins that run right underneath the skin of the legs. They are totally benevolent generally, aside from perhaps for nonessential reasons. They happen in ladies just somewhat more regularly than they do in men, and ten to thirty percent of individuals have them. Thanks a lot~ Dr. Jay Amin

Robero said...

I just loved this. This is a wonderful piece of work. I would like to add some thing to what DrJayUSA said. Varicose veins are unsightly enlarged veins that stick out prominently from your skin – are a common medical issue. They are a vein or vein that appears twisted or enlarged along your skin’s surface – often in the legs and ankles — and are a cosmetic blemish that usually do not cause any serious health complications, though it’s possible they could trigger health problems. Varicose veins are caused by weakened valves in your veins. These valves are one-way and ensure blood flows from your legs to your heart.
This I happened read from a blog of Vaughan vein clinic at Toronto. Thought of adding it here,so that it might be useful to someone who goes through this wonderful article.

Life Extension said...

Robero- Thanks for sharing this information with us and for stopping by our blog!

Ramayi said...

Before taking any treatment we should consult with doctor always. I preferred the venorid cream for varicose vein. After purchase i consulted with my Doctor. She granted to use this and i was very satisfied with result.

Life Extension said...

Ramayi - It is always a good idea to discuss your supplement regimen with your doctor first. :)

Siresten said...

I got varicose vein due to long day sitting in my office. one of my collique refereed venorid for solution. I tried after some weeks, some what smoother area i got.

Life Extension said...

Siresten - Thanks for sharing this information with us.

Post a Comment

Related Posts Plugin for WordPress, Blogger...
All Contents Copyright © 1995-2016 Life Extension® All rights reserved.
Privacy Policy | Terms of Use
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You should not stop taking any medication without first consulting your physician.