Diabesity... The New Epidemic

By Michael A. Smith, MD

Diabesity... The New EpidemicThere’s a new epidemic on the rise and it’s called Diabesity. Life Extension® has long warned its members of the dangerous link between high blood sugar and obesity. What links these two deadly diseases is inflammation.

If you are having a hard time controlling blood sugar or losing weight, the problem could be inflammation. Targeting the inflammatory pathways with a few key nutrients may help you finally get control of your health.

Inflammation is an immune response that occurs after infection or injury. It involves a series of biological actions that leads to the development of redness, heat and swelling. All of these elements are created by the activity of immune cells working to break down injured and dying tissues so that new, healthy ones can replace them.

As people age, systemic inflammation can inflict degenerative effects throughout the body.1 A primary cause of this destructive cascade is the production of inflammatory proteins. It is the inflammatory proteins that may interfere and hamper your efforts to control blood sugar or lose weight.
Here are three great suggestions for easing inflammation …

Omega-3 Fatty Acids

An abundance of scientific research substantiates the wide-ranging health benefits of omega-3 fatty acids in fish oil.2 The primary omega-3 fats are EPA and DHA. Supplementing with approximately 1400 mg of EPA and 1000 mg of DHA can help to ease inflammation through a variety of mechanisms.

When purchasing a fish oil product, look for one with sesame lignans. These important fat preservatives help guard against lipid peroxidation, thereby extending the stability of omega-3 fats in the body. Sesame lignans also direct omega-3 fatty acids toward pathways which can help ease inflammatory reactions.

5-Loxin from Boswellia

Inflammation in the body starts with excess arachidonic acid and increased activity of the 5-lipoxygenase (5-LOX) enzyme. Blocking the 5-LOX enzyme may help to ease inflammation throughout the body.

5-loxin is an extract from Boswellia that inhibits the 5-LOX enzyme. Supplementing with 75 mg/day should help ease inflammation.

Theaflavin from Black Tea

Have you heard that black is the new green tea? Black tea extracts contain a number of beneficial antioxidants found naturally in the tea leaves. One in particular called theaflavin helps support normal levels of inflammation.3

The theaflavin compound favorably expresses genes that help modulate and regulate inflammation. This concept of nutrients affecting genes is called Nutrigenomics. Theaflavin has been shown in human studies to protect against LDL oxidation and favorably affect endothelial function, thus helping to maintain healthy circulation.


  1. Paris D, et al. AB vasoactivity: an inflammatory reaction. Ann N Y Acad Sci. (no date provided) pp.97-108.
  2. Public Health Nutr. 2006 Dec;9(8A):1136-40.
  3. J Lipid Res. 2007 Nov;48(11):2334-43.


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